苏乐斌，特聘教授，博士

联系电话：0731-88872530

办公地点：402永利集团

研究方向：催化合成&智能生物转化

邮箱：su_lebin@hunnu.edu.cn

基本信息：苏乐斌，“潇湘学者”特聘教授，主要研究领域包括C≡C/N键选择性转化、化学数据库构建、自动化库合成、高通量实验筛选以及药物合成。2021湖南省优秀博士学位论文、2022广州国家实验室优秀共产党员、2023广州实验室年度考核优秀、2024第十二届岭南有机化学会议优秀青年报告奖。目前主持国家自然科学基金面上和青年项目各1项，广东省自然科学基金2项，参与广州国家实验室重大项目——抗肺部肿瘤药物靶点鉴定与药物研发，申请并授权专利5项。近年来，共发表学术论文30余篇，其中以第一/通讯作者身份在Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Sci., Sci. China Chem., Org. Lett.等国际权威期刊上发表论文16篇。研究成果发表后，多次获Chin. J. Org. Chem.、Synfacts、Organic Chemistry Portal等期刊专题报道或亮点评述。其中，关于炔烃选择性6-endo-dig环化制备1-萘胺的工作被国家自然科学基金委员会遴选为突出成果，并收录于《Science Foundation in China》。此外，有机磷合成方向的研究亦获《中国科学：化学》重点推介。

邮箱：15084898092@163.com; su_lebin@hunnu.edu.cn。

课题组主页：https://www.x-mol.com/groups/Su_Lebin

教育和工作经历：

2025.7-至今，402永利集团，“潇湘学者”特聘教授

2021.5-2025.6，广州国家实验室，副研究员

2019.10-2021.4，生物岛实验室，副研究员

2015.9-2019.4，湖南大学，有机化学，理学博士，导师：周永波教授

2013.9-2015.6，湖南大学，有机化学，硕博连读，导师：周永波教授

2009.9-2013.6，湖南城市学院，生物工程，工学学士，导师：肖谷清教授

研究领域：

新反应发现：

1.铜催化炔烃转化

2.碳-碳/氮键构建

3.细胞内的偶联反应

主持和参与的科研项目：

402永利集团“潇湘学者”特聘教授启动基金，主持

国家自然科学基金面上项目，22372044，人工智能辅助的氮杂环碳氮键断裂与选择性转化反应研究, 2024.01-2027.12，主持

国家自然科学基金青年项目，22002169，基于炔烃选择性官能团化合成腈类化合物的研究，2021.01-2023.12，主持

湖南省芙蓉计划青年人才项目，2025RC3144，2025.07-2028.07，主持

广东省自然科学基金面上项目，2024A1515012583，人工智能辅助的氮杂芳腈化合物的精准合成，2024.01-2026.12，主持

广东省区域联合基金青年项目，2019A1515111111，基于芳酮与硫叶立德反应及其应用研究，2020.01-2022.12，主持

国家自然科学基金面上项目，22071249，基于高通量实验和深度学习建立酰胺合成反应预测模型的方法研究，2021.01-2024.12，参与

代表性论文：

1）Lebin Su^#, Jianyu Dong^#,*, Yang Shen^#, Shimin Xie, Shaofeng Wu, Neng Pan, Feng Liu, Qian Shang, Fangfang Cai, Tian-Bing Ren*, Lin Yuan, Shuang-Feng Yin*, Li-Biao Han, Yongbo Zhou*, General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines, Nat. Commun. 2025, 16, 169.

2）Guoming Tong^#, Changfeng Li^#, Qing Zhou, Fang Wang, Wei He, Erhu Xiong, Lebin Su*, Sheng Yang*, Guhuan Liu*, Ronghua Yang, Biomarker-Gated Photocatalysis Uncaging in Live System, Angew. Chem. Int. Ed. 2026, 65, e15936.

3）Haiting Wu^#, Yougen Xu^#, An Lin, Zhi Wang, Huanjun Chen, Xinwei Zhu, Yadong Gao*, Lebin Su*,Direct synthesis of α-functionalized amides via heteroatom–hydrogen insertion reactions using amide-sulfoxonium ylides. Nat. Commun. 2024, 15, 10207.

4）Yougen Xu^#, Yadong Gao^#, Lebin Su*, Haiting Wu, Hao Tian, Majian Zeng, Chunqiu Xu, Xinwei Zhu, Kuangbiao Liao*, High-Throughput Experimentation and Machine Learning-Assisted Optimization of Iridium-Catalyzed Cross-Dimerization of Sulfoxonium Ylides, Angew. Chem. Int. Ed. 2023, 62, e202313638.

5）Lebin Su^#, Tianbing Ren^#, Jianyu Dong*, Lixin Liu, Shimin Xie, Lin Yuan*, Yongbo Zhou*, Shuang-Feng Yin, Cu(I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties, J. Am. Chem. Soc. 2019, 141, 2535−2544.

6）Lebin Su^#, Jianyu Dong^#, Long Liu, Mengli Sun, Renhua Qiu, Yongbo Zhou*, Shuang-Feng Yin*, Copper Catalysis for Selective Heterocoupling of Terminal Alkynes, J. Am. Chem. Soc. 2016, 138, 12348−12351.

7）Haiting Wu^#, Yougen Xu^#, An Lin, Jingyuan Liu, Huanjun Chen, Shimin Xie*, Lebin Su*,Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides, Adv. Sci. 2025, 12, 2417362.

8）An Lin, Jingyuan Liu, Yougen Xu, Haiting Wu, Yating Chen, Yan Zhang, Lebin Su*, Xiaodan Zhao, Kuangbiao Liao*, High-Throughput Experimentation and Machine Learning-Promoted Synthesis of α-Phosphoryloxy Ketones via Ru-Catalyzed P(O)O–H Insertion Reactions of Sulfoxonium Ylides, Sci. China Chem. 2025, 68, 679−686.

9）Jian Lei^#, Lebin Su^#，Kui Zeng^#, Tieqiao Chen^#, Renhua Qiu, Yongbo Zhou, Chak-Tong Au, Shuang-Feng Yin*, Recent advances of catalytic processes on the transformation of alkynes into functional compounds, Chem. Eng. Sci. 2017, 171,  404−425.

10）Yougen Xu, Feixiao Ren, Lebin Su*, Zhaoping Xiong, Xinwei Zhu, Xinyuan Lin, Nan Qiao, Hao Tian, Changen Tian, Kuangbiao Liao*, HTE and machine learning-assisted development of iridium(I)-catalyzed selective O–H bond insertion reactions toward carboxymethyl ketones, Org. Chem. Front. 2023, 10, 1153–1159.

11）Lebin Su^#, Shimin Xie^#, Jianyu Dong*, Feng Liu, Shuang-Feng Yin, Yongbo Zhou*, Copper-Catalyzed Nitrogen Atom Transfer to Isoquinolines via C−N Triple Bond Cleavage and Three-Component Cyclization, Org. Lett. 2022, 24, 5994−5999.

12）Lebin Su^#, Shimin Xie^#, Jianyu Dong*, Neng Pan, Shuang-Feng Yin, Yongbo Zhou*, Copper-Catalyzed 6-endo-digCyclization−Coupling of 2‑Bromoaryl Ketones and Terminal Alkynes toward Naphthyl Aryl Ethers in Water, Org. Lett. 2022, 24, 4569−4574.

13）Qiang Wang*, Xing Zhang, Xianglin Zhuang, Liwen Xia, Yingwei Wang, Xianrong Cai, Xingyong Liang*, Lebin Su*, Electrochemical Dehydrogenative and Desulfurative Annulation for the Synthesis of Isoxazolines and Pyrazolines, Org. Chem. Front. 2025, 12, 2739−2745.

14）Lebin Su, Kang Sun, Neng Pan, Long Liu, Mengli Sun, Jianyu Dong*, Yongbo Zhou*, Shuang-Feng Yin,Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines, Org. Lett. 2018, 20, 3399−3402.

15）Shimin Xie^#, Lebin Su^#, Min Mo, Wang Zhou, Yongbo Zhou, Jianyu Dong*, Cu-Catalyzed Oxidative Thioesterification of Aroylhydrazides with Disulfides, J. Org. Chem. 2021, 86, 739−749.

16）Baiqing Li, Shimi Su, Chan Zhu, Jie Lin, Xinyue Hu, Lebin Su, Zhunzhun Yu, Kuangbiao Liao*, Hongming Chen*, A deep learning framework for accurate reaction prediction and its application on high-throughput experimentation data, J. Cheminform. 2023, 15, 72.

17）Feng Liu^#, Jianyu Dong^#,*, Ruofei Cheng^#, Shuang-Feng Yin, Lang Chen, Lebin Su, Renhua Qiu, Yongbo Zhou*, Li-Biao Han, Chao-Jun Li*, Direct carbonyl reductive functionalizations by diphenylphosphine oxide. Sci. Adv. 2025, 11, eads4626.